TIM-3 Expression in Breast Cancer

TIM-3 is an immune biomarker that is currently targeted by new immunotherapy drugs. Our study reports the first large-scale evaluation of TIM-3 expression based on our examination of nearly 4,000 breast cancers from the province of British Columbia. We report that TIM3 is present in more than a quarter of patients with a basal-like breast cancer, an aggressive cancer type with no targeted therapy. The findings from our publication imply that patients with basal-like breast cancers can potentially be amenable to immunotherapies targeting TIM-3.
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Everyone benefits when our labs and classrooms look more like the Canada we see today. Diverse perspectives bring new ideas and drive creativity in science and research, which lead to innovations that help grow the economy. The next generation of young researchers brings fresh thinking to science problem solving and discovery, which helps keep Canadian research at the forefront of…
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A new discovery by an international research team—co-led by UBC Canada 150 Research Chair Josef Penninger and Harvard Medical School neurobiologist Clifford Woolf—could have implications for therapies for cancer and autoimmune diseases. In a study published today in Nature, researchers outline a new understanding of the biology of T cells, a type of immune cell in the body, that demonstrates how…
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A Novel Approach to Outsmart Prostate Cancer

Prostate cancer researchers find new target for drug therapy. Prostate cancer is the most common cancer in men. While incidences of the disease are declining, roughly 21,000 Canadian men are still diagnosed each year, with 1 in 29 cases taking an aggressive and deadly form. At the Vancouver Prostate Centre (VPC), Vancouver Coastal Health Research Institute scientists, Dr. Artem Cherkasov…
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Each year, about 1 in 10 babies worldwide are born before the pregnancy has reached full term. Using samples of tissue collected from donated placentas from preterm births with and without inflammation, we examined DNA methylation, a chemical mark on DNA that is associated with how genes are turned on and off in the cell. We were able to identify unique DNA methylation changes in the placenta associated with inflammation in preterm birth pregnancies.
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Over the next 10 years, studies suggest, B.C. will lose two million jobs—but will gain three million more. The catch? We don’t know what they might be. Technology is moving so fast that it is estimated that two-thirds of students entering elementary school today will be employed in professions that currently don’t exist. Given the rise of computing and automation,…
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A short walk down the hall behind the information desk at Vancouver General Hospital (VGH), in the laboratory medicine wing, is a new resource for Vancouver Coastal Health researchers – a collection space devoted specifically to blood work for research studies. The new service is possible due to support from the Vancouver Coastal Health Research Institute (VCHRI) and the Hematology…
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Affordability makes precision health more accessible The ‘one-size-fits-all’ approach to health care is nearing an end ushering in the era of precision. The future of health care lies in harnessing the power of molecular approaches embodied in modern genomics. Today, sequencing the human genome costs around $1000 and it can be done in just a couple of days. It is…
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Genomic rearrangements in the MYC locus occur in ∼12% of lymphomas with diffuse large B-cell lymphoma (DLBCL) morphology and are associated with inferior outcome. Previous studies exploring MYC rearrangements have primarily used fluorescence in situ hybridization (FISH) assays to characterize break-apart status but have rarely examined breakpoint location, and in some cases have not examined partner identity. We performed targeted sequencing of MYC, BCL2, BCL6, and the…
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Far from a classroom exercise happening behind the walls of the ivory tower, university research is a fundamental component of Canada’s economic health – both today and into the future. Some of our country’s greatest inventions and world-renowned accomplishments, such as canola and insulin, have happened on the nation’s university campuses. Universities in Canada carry the country’s burden of research…
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