MS Researher-Led Event Encourages Teenagers to Choose Science

In Grade 10, fifteen- and sixteen-year-olds begin making the academic decisions that may shape their lives, opting for electives in the sciences or the arts. What they choose will influence where they plan to go to university, what they plan to study, and who they ultimately become. For many scientists, their earliest interest in science is sparked by someone else.…
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 Pascal Biosciences Inc. (TSX.V:PAS) (“Pascal” or the “Company”) today announced the Company has discovered certain cannabinoids that enhance the immunogenicity of tumor cells, rendering them more susceptible to recognition by the immune system. This discovery is important because the leading class of new cancer fighting agents, termed “checkpoint inhibitors”, activates the immune system to destroy cancer cells. Enhancing recognition of cancer…
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More than half of government scientists in Canada—53%—do not feel they can speak freely to the media about their work, even after Prime Minister Justin Trudeau’s government eased restrictions on what they can say publicly, according to a survey released today by a union that represents more than 16,000 federal scientists. That union—the Professional Institute of the Public Service of Canada…
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A Vancouver team led by TFRI-funded investigator Dr. David Huntsman has discovered an important therapeutic target for treating small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). This is a rare, but extremely lethal, ovarian cancer in young women with no effective treatment. The present study, published in The Journal of Pathology (June 2017), suggests that SCCOHT tumour cells need the activity of…
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Various kinases, including a cyclin-dependent kinase (CDK) family member, regulate the growth and functions of primary cilia, which perform essential roles in signaling and development. Neurological disorders linked to CDK-Like (CDKL) proteins suggest that these underexplored kinases may have similar functions. Here, we present the crystal structures of human CDKL1, CDKL2, CDKL3, and CDKL5, revealing their evolutionary divergence from CDK and mitogen-activated…
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Dr. Natalie Strynadka is a Distinguished Professor and researcher in the Department of Biochemistry and Molecular Biology at the University of British Columbia and a member of the Centre for Blood Research (CBR). She is known for her research in the fields of antibiotic resistance and biophysics. Dr. Strynadka recently received the honour of being chosen as the 2018 Fellow…
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New MS Model Provides Hope for Better Understanding of Disease Pathology

Until now, researchers studying multiple sclerosis (MS) in mouse models have relied on models heavily weighted towards processes secondary to an autoimmune trigger. While discoveries made through these models have informed later translational research and clinical trials to improve drug treatment for people living with MS, a lack of a model for the unique biological process by which the disease…
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Congratulations to the CIHR 2017 Project Grant Recipients

We are pleased to congratulate the BC Children’s and BC Women’s investigators who were awarded funding from the Canadian Institutes of Health Research (CIHR) Fall 2017 competitions. Our research community received more than $8 million in new grants and awards. BC Children’s and BC Women’s investigators obtained 10 of the 59 full Project Grants awarded to UBC. Most of the investigators…
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Acute infection is known to induce strong anti-tumor immune responses, but clinical translation has been hindered by the lack of an effective strategy to safely and consistently provoke a therapeutic response. These limitations are overcome with a novel treatment approach involving repeated subcutaneous delivery of a Klebsiella-derived investigational immunotherapeutic, QBKPN. In preclinical models of lung cancer, QBKPN administration consistently showed anti-cancer…
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The British Columbia-led Digital Technology Supercluster is one of the funding recipients for the Government of Canada’s Innovation Supercluster Initiative, Minister Navdeep Bains announced today. In May 2017, Minister Bains announced a nationwide initiative to create up to five superclusters that will supercharge Canada’s regional innovation ecosystems and “build Canada as a global centre for innovation.” Superclusters are innovation hotbeds,…
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