In this publication we explain the long-term effect of salt stress in the proteins that act as bridges between cellular organelles in leaf tissues. Our results shows that, in response to salt stress, proteins that act as molecular bridges are activated and create communication pathways between two plant organelles, the endoplasmic reticulum and the plasma membrane,. This mechanism is a specialized cellular adaption that, in plants, enables the cellular adaptation to sustained stress conditions commonly found during their life cycle...
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Phoenix Molecular Designs (PhoenixMD), a privately-held biotechnology company designing precise cancer therapeutics by targeting essential kinases, announced that it has entered into a collaboration with Roche to develop a diagnostic (CDx) in triple-negative breast cancer (TNBC).  The Roche CDx identifies RSK2 activation in human tumors. In cancer, the PDK-1 and MAPK pathways converge on RSK2 to activate it, moving it…
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Scientists have managed to grow perfect human blood vessels as organoids in a petri dish for the first time. The breakthrough engineering technology, outlined in a new study published today in Nature, dramatically advances research of vascular diseases like diabetes, identifying a key pathway to potentially prevent changes to blood vessels—a major cause of death and morbidity among those with…
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Domesticated plants and animals often display dramatic responses to selection, but the origins of the genetic diversity underlying these responses remain poorly understood. Despite domestication and improvement bottlenecks, the cultivated sunflower remains highly variable genetically, possibly due to hybridization with wild relatives. To characterize genetic diversity in the sunflower and to quantify contributions from wild relatives, we sequenced 287 cultivated…
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While many Canadian academics were enjoying a bit of time off over the holidays, some early-career researchers were scrambling to put together applications for the New Frontiers in Research Fund (NFRF), the new funding program designed to support risky interdisciplinary research. The NFRF was first announced last spring in the 2018 federal budget, with investments of $275 million over five…
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Controlling Blood Pressure Protects Cognitive Health after Spinal Cord Injury

When people think of spinal cord injury (SCI) they tend to focus on paralysis and body movement. But post-injury, the biggest health risk is actually cardiovascular disease— it’s the number one cause of disability and death in people with SCI. Vancouver Coastal Health Research Institute scientists at ICORD (The International Collaboration on Repair Discoveries) are focusing on cardiovascular problems in…
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On behalf of Dr. Francois Bénard, Vice President Research, and Dr. Pamela Hoodless, Director, Terry Fox Laboratory, please join us in welcoming Dr. Kevin Hay, a newly appointed Clinician-Scientist, to the Terry Fox Laboratory and the Leukemia/Bone Marrow Transplant Program of BC. Kevin received his Master of Science in Immunology at the University of Manitoba (2008), followed by an MD…
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Higher plants utilize nucleotide-binding leucine-rich repeat domain proteins (NLRs) as intracellular immune receptors to recognize pathogen-derived effectors and trigger a robust defense. The Activated Disease Resistance 1 (ADR1) family of coiled-coil NLRs (CNLs) have evolved as helper NLRs that function downstream of many TIR-type sensor NLRs (TNLs). Close homologs of ADR1s form the NRG1 family in Arabidopsis, the function of…
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Thrombosis, the formation of a potentially deadly blood clot, remains one of the leading causes of death and disability worldwide. Once formed, clots can slow or obstruct normal blood flow, leading to damage to surrounding tissue. In deep vein thrombosis, a blood clot forms in the veins deep inside the body between large muscle groups, most commonly in the leg…
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