Assessment of autophagy activity has historically been limited to investigations of fixed tissue or bulk cell populations. To address questions of heterogeneity and relate measurements to functional properties of viable cells isolated from primary tissue, we created a lentiviral (RFP-GFP-MAP1LC3B) vector that allows the autophagosome and autolysosome content of transduced cells to be monitored at the single-cell level. Use of…
Read More
Symvivo Corporation, a clinical-stage biotechnology company advancing a proprietary bacTRL™ gene delivery platform, announced today that it has entered into a research collaboration with Janssen Biotech, Inc. (Janssen), one of the Pharmaceutical Companies of Johnson & Johnson. Under the terms of the agreement, Janssen will have the exclusive option to research, develop and commercialize novel biological therapeutic candidates based on…
Read More

Voicing the Silent Genomes: New Documentary Features GSC Scientist, Dr. Nadine Caron

The vision of precision medicine is customized health care—preventative measures, disease treatments, practices and products tailored to individuals. Genomics is leading the charge by investigating and cataloguing the chemistry of life using an ever-increasing range of nucleic acid sequencing techniques and powerful computational technologies. But what if the genomic information that is being databased and used to inform modern medical…
Read More
Previous research from the authors identified that people with a gain-of-function DNA variant in a gene called CETP have lower levels of HDL cholesterol (the “good cholesterol”) during sepsis and a higher risk of death. In this study, they tested the hypothesis that inhibiting CETP using a drug would improve outcomes from sepsis. They performed this work in a mouse model of experimental sepsis, and showed that inhibiting CETP resulted in preservation of HDL levels and improved survival from sepsis.
Read More
Research by scientists at the University of British Columbia (UBC) and the BC Cancer Research Institute (BCCRI) has uncovered a new combination treatment that may overcome drug resistance in pancreatic cancer, one of the most deadly cancers.The study, recently published in Cell Reports Medicine, identified a new combination treatment strategy that prevents a type of pancreatic tumour, known as pancreatic ductal…
Read More

Beyond Kinases: Targeting Replication Stress Proteins in Cancer Therapy

DNA replication stress describes a state of impaired replication fork progress that triggers a cellular stress response to maintain genome stability and complete DNA synthesis. Replication stress is a common state that must be tolerated in many cancers. One promising therapeutic approach is targeting replication stress response factors such as the ataxia telangiectasia and rad 3-related kinase (ATR) or checkpoint…
Read More
adMare BioInnovations, Canada’s global life sciences venture, is proud to announce the launch of its new BioInnovation Scientist (BIS) program, a multi-year progressive training program focused on helping transition strong academically-trained scientists into commercially-minded industry scientists. Successfully meeting the health and economic challenges in front of Canadians requires innovative scientists who are focused on rapid, efficient life sciences technology development…
Read More

The GSC Welcomes Dr. Laura Evgin

The GSC is pleased to announce the arrival of our newest faculty member, Dr. Laura Evgin. As of November 2, she is Scientist at the GSC and an Assistant Professor in the Department of Medical Genetics at the University of British Columbia. Dr. Evgin’s research is focused on Chimeric antigen receptor (CAR) modified T cells and oncolytic viruses. CAR T cells CAR…
Read More
COVID toes led an international group of researchers to identify a previously unknown role of Immunoglobulin A (IgA) in severe COVID-19. To date, over 50 million people have been affected by COVID-19 since the start of the pandemic. More than one million deaths have resulted from a range of virus-associated causes and complications, including acute respiratory distress syndrome and blood…
Read More

Communal Living: Glycan Utilization by the Human Gut Microbiota

Our lower gastrointestinal tract plays host to a vast consortium of microbes, known as the Human Gut Microbiota (HGM). The HGM thrives on a complex and diverse range of glycan structures from both dietary and host sources, the breakdown of which requires the concerted action of cohorts of Carbohydrate‐Active Enzymes (CAZymes), carbohydrate‐binding proteins, and transporters. The glycan utilization profile of…
Read More