Several studies have now shown that previously reported function roles of H3K4 methylation are likely due to the co-activator activity of the complex that catalyzes H3K4 methylation. To address what role H3K4 methylation might play in pancreas development, we knocked out a component of this complex called the TrxG complex, that allows the complex to maintain its co-activator activity, but preventing it from catalyzing H3K4 methylation. They found that H3K4 methylation is essential for maintenance of the expression of terminal markers that are essential for acinar cell identity and function.
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NGen has approved Supercluster funding for a transformative $4.2 million project led by iVexSol Canada to develop an advanced manufacturing process for lentiviral vectors. These gene-editing reagents are critical components in the manufacturing processes of cell and gene therapies (CGTs), which have been successfully employed to fight cancer and repair a variety of rare and inherited genetic disorders in both children…
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Simon Fraser University assistant professor Nadine Provençal and researchers from the Max Planck Institute of Psychiatry in Germany have identified a “cellular memory” that could help explain how fetal exposure to stress during pregnancy affects how we respond to stress exposure later in life. “The prenatal period is one of the most dynamic and sensitive periods in a person’s life,”…
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A big goal of genomics is to try to understand how genes are regulated, that is, how a cell controls when a gene is “on” or “off”. The authors showed that coexpression doesn’t have a lot to do with regulation, at least not at a fine granularity. Instead, it tells you about which genes are expressed in which cell types. They compared coexpression between single-cell data and brain tissue. They also discuss the possibility of correcting tissue-level data for the cell-type effects.
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Dr. Edmond S. Chan, UBC clinical associate professor and head of the division of allergy & immunology in the department of pediatrics at UBC, is the winner of the 2019 Robyn Allen Leadership Award. The award recognizes an individual who has made a unique contribution to the lives of Canadians with food allergy through their efforts in education, advocacy, community building,…
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The Canadian government is scrambling to respond to a glut of license applications for cannabis research prompted by the drug’s legalization in October 2018. The queue of applicants—there were 251 in line as of late July—and the attendant monthslong waiting times are frustrating scientists interested in the basic biology and therapeutic possibilities of cannabis. The delays are also prompting criticism…
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The University of British Columbia was announced as one of the 17 institutions selected to participate in the Dimensions: equity, diversity and inclusion Canada pilot program (Dimensions). The announcement was made by the Honourable Kirsty Duncan, Minister of Science and Sport and the Honourable Bill Morneau, Minister of Finance at Ryerson University. The Dimensions pilot progam and accompanying charter, which UBC…
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New research published this week in JAMA Oncology has found a lack of racial and ethnic diversity in clinical trials for cancer drugs. The study—conducted by researchers from UBC, the University of Texas MD Anderson Cancer Center, the Fred Hutchinson Cancer Center in Seattle and Baylor University in Texas—raises concerns about the effectiveness of cancer drugs in some patients, especially since genetic…
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Science and research are integral to the transformative discoveries and innovations that improve the lives of all Canadians. New medical breakthroughs, quantum computing technologies and innovative agricultural practices would not be possible without the creative ideas of our talented researchers. That’s why the Government of Canada has provided historic support to Canadian researchers and given them the tools they need…
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A coalition of science groups is pushing for candidates in the upcoming federal election to back evidence-informed policy, more transparent communication of that decision-making and more funding for scientific research. The “Vote Science” campaign, which launched Thursday, includes a toolkit to help Canadians engage with candidates directly, and questionnaires will be sent to political parties to identify their positions on the…
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