Four Therapeutic Lung Studies Now Underway at St. Paul’s

Four new inflammatory airway disease trials are underway with the support of CHÉOS — staff will be providing coordinating and site management services. Dr. Del Dorscheid, a critical care and respiratory physician at St. Paul’s Hospital and researcher at the Centre for Heart Lung Innovation, is the principal investigator for all four of the studies. Three of the studies are examining…
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HAM-TBS: High-Accuracy Methylation Measurements via Targeted Bisulfite Sequencing

Dr. Provençal’s research group aims to understand the molecular mechanisms of how early life environmental exposures influence the development of an individual leading to disease versus health. The laboratory uses a translational approach to study the epigenetic mechanisms involved in the long-lasting effects of early life adversities and their impact on the developmental trajectories of behavioral and stress-related disorders…
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TxCell, a developer of cellular immunotherapies based on regulatory T cells (Tregs) for inflammation, autoimmunity and transplantation, today announces it has exercised its exclusive option to in-license the intellectual property rights of one of its academic partners, the University of British Columbia (UBC), onto the HLA-A2 CAR-Treg program. This program, named TX200 in TxCell’s portfolio, should soon be tested in human…
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There are so many benefits to basic research, where scientists work to uncover new knowledge and develop new technology without any particular commercial application in mind. These are the truly transformative moments in science, because these discoveries unlock possibilities that no one could have predicted. But there’s another benefit that comes with simply doing basic research: we grow the next…
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CHÉOS Scientists Awarded CIHR Project Grants

The results of the CIHR Project Grant Competition for March 2018 were announced today. A total of 369 grants were funded with a success rate of 14 per cent. Of those grants, 4 are led by CHÉOS Scientists with 16 Scientists serving as co-investigators on 9 individual projects. Dr. Karin Humphries will serve as principal investigator, along with Dr. Jim Christenson (PHC/UBC…
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Breakthrough discovery from UBC researcher discovers that permanent lung damage caused by chronic obstructive pulmonary disease (COPD) starts before patients even begin showing symptoms.  The discovery was made by Dr. Tillie-Louise Hackett, associate professor in the University of British Columbia’s faculty of medicine, that will drastically change how patients are treated for COPD, and is the leading cause of hospital…
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Plant specialized metabolism serves as a rich resource of biologically active molecules for drug discovery. The acylated flavonol glycoside montbretin A (MbA) and its precursor mini-MbA are potent inhibitors of human pancreatic α-amylase and are being developed as drug candidates for the treatment of type-2 diabetes. MbA occurs in corms of the ornamental plant montbretia (Crocosmia x crocosmiiflora), but a…
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The UBC Faculty of Medicine is pleased to recognized the Women’s Health Research Institute (WHRI) as a Faculty of Medicine Research Center, in recognition of its scientific contributions and its significance to the Faculty of Medicine’s mission and to the public’s health. By coming within the Faculty’s organizational structure as the Women’s Health Research Centre, WHRI will now have a…
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On October 20, marijuana will no longer be an illegal drug in Canada—a move that could make it much easier to study how cannabis affects the body and the brain. “Cannabis has risks and maybe benefits,” says M-J Milloy, an infectious disease epidemiologist at the British Columbia Centre on Substance Use and the University of British Columbia who studies HIV patients’…
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Untangling the Brain’s “Wires” in the Virtual Space

The brain’s cells interact with one another in a very dense environment, some of them rearranging the exquisite network of cells when pruning old bits of neuron to form new connections and stronger lines of communication, or when repair is needed following injury. It is a dynamic process, and images in a textbook cannot convey the complexity of cell-to-cell interaction…
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