Single-cell transcriptomics provides an opportunity to characterize cell-type-specific transcriptional networks, intercellular signaling pathways and cellular diversity with unprecedented resolution by profiling thousands of cells in a single experiment. However, owing to the unique statistical properties of scRNA-seq data, the optimal measures of association for identifying gene-gene and cell-cell relationships from single-cell transcriptomics remain unclear. Here, we conducted a large-scale evaluation…
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The NanoMedicines Innovation Network (NMIN) has been awarded $18.5 million in new funding from the Networks of Centres of Excellence (NCE), a federal program that connects teams of scientists across Canada to collaborate on research with significant health, environmental and societal impacts. This funding is matched by more than $22 million from industry and other not-for-profit agencies. The funding will maintain and extend Canada’s…
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Inherited metabolic disorders — where the body can’t break down specific nutrients from food leading to a range of serious health problems — are often caused by a defective gene. In this important study, researchers found an unusual genetic mutation behind three children’s undiagnosed, degenerative conditions: a repeat expansion of DNA. In this specific mutation, the gene appears undamaged but…
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Dr. Sriram Subramaniam first met Dr. Gobind Khorana at MIT in 1987 where he joined Khorana’s team as a post-doctoral researcher studying the proteins involved in light absorption. Khorana was already a Nobel Laureate, having won the prize in 1968 with two colleagues ‘for their interpretation of the genetic code and its function in protein synthesis’. Khorana quickly became a mentor…
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Final Decision on the Foundation Grant Program

When CIHR created the Foundation Grant program, it was with the intent to support health researchers across all four pillars who were highly successful in the open grants programs. The goal was to support them in a way that would allow them to have the flexibility to pursue new and innovative lines of inquiry, while also training and mentoring the…
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Two internationally recognized researchers join the University of British Columbia as Canada Excellence Research Chairs, bringing international talent in the fields of forest bioproducts and precision cancer drug design. Orlando Rojas has accepted the Canada Excellence Research Chair in Forest Bioproducts, while Sriram Subramaniam will hold the Gobind Khorana Canada Excellence Research Chair in Precision Cancer Drug Design—named after late Nobel Prize-winning UBC biochemistry…
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Nancy Harrison, Chair, LifeSciences BC Board of Directors, announced today the appointment of Wendy Hurlburt, as the organization’s new President and CEO. “We are very pleased to have Wendy join and lead our team; as she brings a strong business background in pharmaceutical, not-for-profit and operations management to this executive position. This is an exciting time for our sector and…
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SFU PhD candidate Careesa Liu’s research focuses on relatively small areas of the brain, but her view of science and technology is much bigger. A biomedical engineer, Liu is completing her PhD at the NeuroTech and ImageTech Labs, both clinically embedded core SFU research facilities near the Surrey campus. She is also working to turn young students from Surrey and…
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The spliceosome has been implicated in genome maintenance for decades. Recently, a surge in discoveries in cancer has suggested that the oncogenic mechanism of spliceosomal defects may involve defective genome stability. The action of the core spliceosome prevents R-loop accumulation, and regulates the expression of genome stability factors. At the same time, specific spliceosomal components have non-canonical functions in genome…
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​These findings are the result of the world’s first randomized clinical trial of SABR as it relates to cancer that has already spread to other parts of the body. The study, led at BC Cancer by Dr. Robert Olson, along with an international team of researchers was recently published in The Lancet. SABR technology is a highly precise form of radiotherapy…
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