Did you know that every second, your blood vessels are being damaged? And every second, they are being repaired? Repair happens through the fascinating process of blood clotting, or coagulation. When a blood vessel is injured ― whether it’s major damage from a stab wound, or minor damage related to pressure and temperature changes ― platelets in the blood stick…
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Blood clots play a part in many severe health issues, from causing strokes and heart attacks to influencing neurodegenerative diseases like Alzheimer’s. Usually, a patient who develops a clot can dissolve it by taking an anticoagulant drug, but risks the common side effect of excessive bleeding. A recent study published by the Kastrup Lab at the Centre for Blood Research and Michael Smith Laboratories helps provide…
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Black Academic Success in Sciences: A Conversation

On February 16, 2021, six members of the SFU Faculty of Health Sciences (FHS) gathered to talk about their experiences in sciences and academia as Black students, faculty, and alumni. This discussion explores the challenges and successes in sciences and academia, and why mentorship and representation matters. Dr. Henrietta Ezegbe is a physician and public health practitioner. She completed her…
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New Evidence Calls into Question Vitamin C as a Treatment for Sepsis

When Dr. Vinay Dhingra first read a study, which seemed to prove the benefits of vitamin C for treating septic shock, he was skeptical. “The study was quite small, and the benefit quite high considering,” recalls the Vancouver Coastal Health Research Institute clinician-scientist who has worked in the Intensive Care Unit (ICU) at Vancouver General Hospital since 1998. A leading…
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Pan-Biome Pharmaceuticals, Inc, a Vancouver based preclinical biopharmaceutical company focused on chronic inflammatory and autoimmune diseases, is pleased to announce that one of its drugs produced strong effects in modulating gut microbiota in a mouse model study of inflammatory bowel disease. In a study run by the Gut4Health Microbiome Core at BC’s Children’s Hospital Research Institute, the compound induced a distinct shift in microbiota composition, by increasing “good” bacteria while suppressing bacteria associated with the development of obesity and type 2 diabetes. Particularly exciting was the finding that our compound induced a substantial…
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Aging Muscle Spindles Contribute to Imbalance and Falls among Older Adults

When the human body is sensing its movement, location and positioning, also known as proprioception, many neural systems are hard at work. Researcher Dr. Robyn Mildren has a keen appreciation for these systems and how their changes due to aging can lead to mobility issues and falls, particularly for older adults. In a paper published in the Journal of Physiology, Mildren and Vancouver…
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DMCBH Staff Highlight: Jeff Ledue

Jeff LeDue wears many “hats” at UBC— he’s a research associate, coordinator of the UBC Dynamic Brain Circuits in Health and Disease Research Excellence Cluster and managing director of the NeuroImaging and NeuroComputation Centre (NINC), a shared research platform at the Djavad Mowafaghian Centre for Brain Health. Upon joining UBC in 2010, LeDue was interested in getting a neurosciencebased imaging…
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Innovative Canadian companies are harnessing the power of sophisticated digital technologies to develop effective therapeutics in entirely new ways. This work involves advanced research at the nexus of multiple disciplines, including microbiology, biochemistry and computer science. The tremendous value of this research became apparent during COVID‑19 with the rapid development and production of vast quantities of both vaccines and therapeutics. The…
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It’s been a little more than a year since scientists and biotech companies around the world pivoted to understanding, treating and preventing COVID-19. Here are five projects to watch led by experts in Canada. Data is expected soon from the phase two clinical trial for APN01, a treatment candidate for COVID-19 developed after the outbreak of SARS in 2002. Dr.…
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As people around the world remain isolated in their homes, avoiding close contact with others and meticulously sanitizing their hands and surfaces, scientists warn there may be unintended consequences of these necessary pandemic protocols. While it’s important to follow public health orders to reduce spread of COVID-19, experts say that all the antibacterial wipes and physical distancing could have long-term…
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