New Tool Enables Researchers to Assemble Transcript Isoforms from Single Cells

The advent of single-cell RNA sequencing technologies has provided unprecedented opportunities for the analysis of transcriptomes at single-cell resolution, allowing researchers to explore cell-to-cell variability. Now, researchers have developed a tool for the analysis and identification of RNA isoforms from single-cell RNA sequencing data. Methodologies for the analysis of single-cell transcriptome data to date have primarily focused on gene expression, but analysis and identification of…
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Imagine that—tens of thousands of bacterial species teeming in every little gram of soil. It might take even greater imagination to see opportunity therein. But ever-innovative Geoscience BC has found ways to analyze the bacteria’s DNA for clues about possible underlying deposits. That’s the topic of the non-profit society’s newly released report, Microbial-Community Fingerprints as Indicators for Buried Mineralization in…
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Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a devastating cancer that has no effective treatments and is usually diagnosed in women in their 20s. The study, published in Clinical Cancer Research, describes a metabolic vulnerability present in cells that may represent a therapeutic target if proven in clinical trials. “Finding this vulnerability and identifying a way to exploit…
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In the midst of a pandemic how can we safely return to work? This question is on the minds of employees, employers, and policymakers as the world begins the process of re-opening during COVID-19. Places that have successfully restricted person-to-person contact have also curbed transmission, but these restrictions come with damaging economic trade-offs. To support decision making around relaxing restrictions…
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LSI researchers have harnessed salmonella’s syringe-like system to inject specific proteins into the fluid that fills cells. More than a quarter of all human proteins are thought to bathe in this milieu, where they interact with one another as well as with proteins from every other cellular compartment. Yet until now, it’s been impossible to efficiently study interactions between those…
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LSI and UBC Faculty of Medicine researchers have found that pH levels may play a key role in the metastasis of esophageal cancer as well as cellular changes that set the stage for its development. The findings, reported in a cover story appearing in Cellular and Molecular Gastroenterology and Hepatology by Postdoctoral Fellow Shane Duggan, UBC Dean of Medicine Dr.…
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Chinook Therapeutics, a biotech company creating targeted therapies for kidney diseases, raised an additional $106 million just before its planned merger with Aduro Biotech. Chinook said it will have at least $275 million in operating capital following the investment and merger. New investors include EcoR1 Capital, OrbiMed, funds managed by Rock Springs Capital, Avidity Partners, Surveyor Capital (a Citadel company),…
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Cancer Drug Synergizes with Radiation Therapy in Treatment-Resistant Prostate Cancer

For some prostate cancer patients, radiation and androgen deprivation therapy—a type of chemotherapy that reduces testosterone levels—synergize to enhance treatment outcomes. But in up to 50 per cent of cases, treatment resistance develops, and the cancer progresses. In a new study published in the journal Cancers, led by GSC Distinguished Scientist Dr. Marianne Sadar, researchers have demonstrated a more effective synergistic treatment…
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AbCellera today announced the acquisition of the OrthoMab bispecific platform from Dualogics, LLC. (Dualogics). OrthoMab is a clinically validated platform that uses the most advanced computational and experimental protein engineering methods to create IgG-like bispecific antibodies from any two antibody sequences. By integrating OrthoMab into its existing technology stack, AbCellera provides the industry with a rapid and complete solution for…
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A new study, published this week in Science Translational Medicine, further refines a potential new treatment that can prevent transplant rejection in kids and adults without leaving them vulnerable to infection. The treatment, which was initially developed by Dr. Megan Levings’ research team, involves genetically engineering specialized immune cells called T regulatory cells (T regs) so that they can dampen down the…
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