Read the Publication  This week we profile a recent publication in Oncotarget from the laboratory of Dr. Xiaoyan Jiang (centre) at the Terry Fox Laboratories. Can you provide a brief overview of your lab’s current research focus? The focus of our translational leukemia research is to identify key molecules and pathways that will lead to new, rationally designed, more effective,…
Read More
The effect of age at first dose on the immunogenicity of a two-dose pediatric schedule of Measles-Mumps-Rubella (MMR) or MMR-Varicella (MMRV) vaccines was assessed in children born to mostly vaccinated mothers. Immunogenicity data among children given their first measles vaccine dose between 11 and 22 months of age were pooled from five randomized controlled trials conducted in Europe and the…
Read More
Every day, 43 children are diagnosed with cancer in North America. Although there have been clear improvements in the treatment of many forms of childhood cancer, the outcome for patients with recurrent or metastatic disease remains dismal and almost unchanged for decades. Moreover, current therapies have very serious side effects on the developing child. This is particularly the case for aggressive childhood cancers such as neuroblastoma, where it is essential to discover targetable alterations typical of cancer cells but which spare normal cells.
Read More
Copaxone is an efficacious and safe therapy that has demonstrated clinical benefit for over two decades in patients with relapsing forms of multiple sclerosis (MS). On an individual level, patients show variability in their response to Copaxone, with some achieving significantly higher response levels. The involvement of genes (e.g., HLA-DRB1*1501) with high inter-individual variability in Copaxone’s mechanism of action (MoA)…
Read More

Effects of Hyperoxia on Dyspnoea and Exercise Endurance in Fibrotic Interstitial Lung Disease

Dyspnoea is a major source of distress and is the hallmark symptom of patients with interstitial lung disease (ILD). Supplemental oxygen may alleviate dyspnoea by attenuating arterial oxygen desaturation, increasing oxygen delivery and reducing the drive to breathe; however, previous studies show conflicting results on the effectiveness of supplemental oxygen on dyspnoea and exercise performance in ILD [1–6]. Methodological factors…
Read More
This work focused on developing a new drug that targeted metastatic tumor nodules exhibiting a multidrug resistant (MDR) phenotype. The results showed that this new compound displayed a half-life of 12 h and selectively targeted the tumor nodules compared to the adjacent normal tissue, significantly prolonging the survival of mice bearing metastatic MDR tumors in mice models of advanced breast and ovarian cancers.
Read More

REVIEW: Modeling the Process of Human Tumorigenesis

Modelling the genesis of human cancers is at a scientific turning point. Starting from primary sources of normal human cells, it is now possible to reproducibly generate several types of malignant cell populations. Powerful methods for clonally tracking and manipulating their appearance and progression in serially transplanted immunodeficient mice are also in place. These developments circumvent historic drawbacks inherent in…
Read More
It has been known for years, mostly from anecdotal reports and a few trials, that ECT not only improves the symptoms of depression, but also has a positive effect on the symptoms of Parkinson’s disease, often on a different timeline than it antidepressant effects. Yet, despite years of research, understanding of the effect of ECT remain elusive. In recent years, my lab has conducted PET studies trying to understand its mechanism of action and maybe determine why a small percentage…
Read More
The Lynn Lab focuses on understanding the development, function and aging of insulin-producing pancreatic ß-cells with the goal of using our knowledge to be able to regenerate the functional ß-cell mass that is lost in those with diabetes. We use both human and mouse models to study ß-cells and are particularly interested understanding how transcription factors alter ß-cell function in health and disease.
Read More

Genetic Modifiers of Multiple Sclerosis Progression, Severity and Onset

The focus of our research is to discover pathogenic mutations leading to the onset of multiple sclerosis in multi-incident families, and the identification of genetic modifiers of disease course and severity. We envision the identification of functionally relevant genetic determinants in multiple sclerosis to define the molecular etiology of disease, provide an immediate means for accurate risk evaluation and early disease diagnosis, reveal novel targets and biomarkers for therapeutic intervention…
Read More