Selective Aggregation of the Splicing Factor Hsh155 Suppresses Splicing upon Genotoxic Stress

When a cell responds to DNA damage it must coordinate DNA repair with changes in both the transcriptome and proteome that together promote recovery and stress tolerance. Using a yeast model, this study identified a new way cells regulate gene expression under stress, namely, by disassembling a splicing complex called SF3B, and sequestering one of its core subunits in a nuclear protein aggregate…
Read More
Much of the published studies have focused on the Atg1 complex from budding yeast Saccharomyces cerevisiae model organism and this complex consists of five core subunits (Atg1, Atg13, Atg17, Atg29, Atg31). Yet, the orthologous ULK complex from humans has a different subunit composition, and in particular contains a unique component called ATG101 in place of two Atg29 and Atg31. It is unclear…
Read More
Oncogenic gene fusions involving Neuregulin 1 (NRG1) have been described as recurrent aberrations in lung adenocarcinomas and had been proposed to represent a druggable signaling axis but this hypothesis had yet to be tested. In the overall POG project, we identified two patients with NRG1 fusion-positive cancers. The first had a primary lung adenocarcinoma, while the second had a primary intrahepatic cholangiocarcinoma, a disease type in which NRG1 fusions have not…
Read More
his is a major Canadian study performed by the Canadian BMT Group and including centres from Canada, Saudi Arabia, New Zealand, and Australia. We found that two donor immune cells suppress chronic graft-versus-host disease (cGvHD) and will be used to guide interventions to minimize development of the disease. It also has resulted in a new focus on NKregs, an immune regulatory…
Read More
Asthma-COPD overlap syndrome (ACOS) or asthma-COPD overlap captures the subset of patients with airways disease who have features of both asthma and chronic obstructive pulmonary disease (COPD). Although definitions of ACOS vary, it is generally thought to encompass persistent airflow limitation in a patient older than 40 years of age with either a history of asthma or large bronchodilator reversibility.…
Read More

REVIEW: When Beta Cells Talk Back

Islet macrophages reside in the perivascular space next to islet blood vessels. They are long-lived and self-renewing, maintaining about two to ten macrophages per islet [1]. However, more than three decades after the first description of islet macrophages [2], our knowledge regarding the biological role of these cells is limited (reviewed in [3]). Emerging evidence indicates that islet macrophages are…
Read More
In this study we used a mouse model of acute lymphoblastic leukemia, the most common pediatric malignancy, to identify the components of an immune response that are necessary to achieve a long-lasting remission. We found that while a response directed against a single target antigen was able to exert early control over leukemia, it was not sufficient to sustain remission; prolonged survival required that the immune response…
Read More
In this study we inserted lumbar drains in patients with acute SCI, and evaluated how monitoring of the cerebrospinal fluid (CSF) pressure around the spinal cord could assist in optimizing the hemodynamic management of these patients.    By showing that the monitoring of CSF pressure (and subsequent calculation of spinal cord perfusion pressure) was a better predictor of neurologic improvement than our standard monitoring…
Read More
The bacterial flagellum is a complex multi-component structure including a whip-like appendage, the flagellar filament, which is composed of approx. 20,000 protein units (flagellins) that link up together and form a structure of about 10 micrometers in length. We discovered and characterized a new family of flagellins…
Read More
First, we show that models of depression in mouse produce brain function changes resembling those observed in humans who are depressed. This, of course, opens up the possibility of testing questions that are prohibitive in humans. As such, we used a next generation fluorescent sensor that allowed us to look at a specific neurotransmitter system…
Read More