This is the first study in CF to evaluate early change in blood protein biomarkers using multiple reaction monitoring mass spectrometry to predict response to pulmonary exacerbation treatment. Several proteins from the blood of CF patients changed during the treatment of pulmonary exacerbations…
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A New Lineage of Eukaryotes Illuminates Early Mitochondrial Genome Reduction

Read the Publication  This week we profile a recent publication in Current Biology from the laboratory of Dr. Patrick Keeling (front, second from right) at the University of British Columbia. Can you provide a brief overview of your lab’s current research focus? Research in the lab is actually not particularly focused on one question, I think in part because diversity is…
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REVIEW: Functional Horizontal Gene Transfer from Bacteria to Eukaryotes

Bacteria influence eukaryotic biology as parasitic, commensal or beneficial symbionts. Aside from these organismal interactions, bacteria have also been important sources of new genetic sequences through horizontal gene transfer (HGT) for eukaryotes. In this Review, we focus on gene transfers from bacteria to eukaryotes, discuss how horizontally transferred genes become functional and explore what functions are endowed upon a broad…
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The VERO study is the first properly designed and powered clinical trial comparing antiresorptive with bone anabolic therapy with fracture as the primary endpoint. Although it makes intuitive sense to first build bone and then preserve improved bone strength, the cost as well as the lack of proven anti-fracture superiority has led to the underutilization of bone anabolic therapy…
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We are interested in developing enrichment or cultivation approaches needed to directly test the hypotheses proposed in the manuscript. We also want to integrate our findings into a recently developed pathway-centric numerical model describing coupled biogeochemical cycling in the Saanich Inlet water column. We use Saanich Inlet as a model ecosystem for studying microbial community…
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In this paper we have generated and characterized a mouse model for Stargardt disease in which the conserved asparagine residue at position 965 in an ATP-binding binding domain of ABCA4 is replaced with serine. This disease-associated missense mutation (N965S) is commonly found in the European and Asian population and a similar mutation in a related transporter ABCA1…
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Regulatory T cells (Tregs) are potent suppressors of immune responses and are currently being clinically tested for their potential to stop or control undesired immune responses in autoimmunity, hematopoietic stem cell transplantation, and solid organ transplantation. Current clinical approaches aim to boost Tregs in vivo either by using Treg-promoting small molecules/proteins and/or by adoptive transfer of expanded Tregs. However, the applicability of…
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There are many scientific challenges to the design of a broadly effective HIV vaccine. One of the longstanding challenges has been the design of a component that can elicit broadly reactive nAbs. One of the target sites on the HIV spike that have been identified through past research are so-called oligomannose sugar molecules that largely coat the virus spike. It has proven challenging to elicit antibodies that can target…
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Frogs play important ecological roles, and several species are important model organisms for scientific research. The globally distributed Ranidae (true frogs) are the largest frog family, and have substantial evolutionary distance from the model laboratory Xenopus frog species. Unfortunately, there are currently no genomic resources for the former, important group of amphibians. More widely applicable amphibian genomic data is urgently…
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Clinical tumors are highly heterogenic that contain many non-tumor cells. In the case of malignant brain tumors, a large portion of cells in the tumor are microglia. Since microglia are not tumor cells, which, by definition, cannot support oncolytic virus replication. Furthermore, we found in the present study that those microglia/macrophages are still infectable by the virus…
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