This work focused on developing a new drug that targeted metastatic tumor nodules exhibiting a multidrug resistant (MDR) phenotype. The results showed that this new compound displayed a half-life of 12 h and selectively targeted the tumor nodules compared to the adjacent normal tissue, significantly prolonging the survival of mice bearing metastatic MDR tumors in mice models of advanced breast and ovarian cancers.
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REVIEW: Modeling the Process of Human Tumorigenesis

Modelling the genesis of human cancers is at a scientific turning point. Starting from primary sources of normal human cells, it is now possible to reproducibly generate several types of malignant cell populations. Powerful methods for clonally tracking and manipulating their appearance and progression in serially transplanted immunodeficient mice are also in place. These developments circumvent historic drawbacks inherent in…
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It has been known for years, mostly from anecdotal reports and a few trials, that ECT not only improves the symptoms of depression, but also has a positive effect on the symptoms of Parkinson’s disease, often on a different timeline than it antidepressant effects. Yet, despite years of research, understanding of the effect of ECT remain elusive. In recent years, my lab has conducted PET studies trying to understand its mechanism of action and maybe determine why a small percentage...
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The Lynn Lab focuses on understanding the development, function and aging of insulin-producing pancreatic ß-cells with the goal of using our knowledge to be able to regenerate the functional ß-cell mass that is lost in those with diabetes. We use both human and mouse models to study ß-cells and are particularly interested understanding how transcription factors alter ß-cell function in health and disease.
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Genetic Modifiers of Multiple Sclerosis Progression, Severity and Onset

The focus of our research is to discover pathogenic mutations leading to the onset of multiple sclerosis in multi-incident families, and the identification of genetic modifiers of disease course and severity. We envision the identification of functionally relevant genetic determinants in multiple sclerosis to define the molecular etiology of disease, provide an immediate means for accurate risk evaluation and early disease diagnosis, reveal novel targets and biomarkers for therapeutic intervention...
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Read the Publication Vancouver, BC – Cultivated sunflowers are one of the five largest oilseed crops in the world and until now sunflower is the last of these crops to have its genome fully sequenced. This genome represents a cornerstone of future work to improve genetic diversity and utilize the sunflower’s stress resistance and ability to grow across different climates.…
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My laboratory is focused on the creation and application of computational software and methods for the analysis of human genome sequences. In particular we increasingly focus on the analysis of non-coding genetic alterations that alter gene expression, and apply our methods to the identification of disease-causing variations for oediatric rare disease (for patients at BC Children's Hospital and around the world).
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My research is and has been focused on the role of genome instability in stem cells in aging and cancer. My lab has a track-record of developing novel research tools, many of which are still in widespread use e.g. commercialized by StemCell and other biotech companies. These include monoclonal antibodies, an IL-6 dependent cell line, cell separation techniques and methods to measure the length of telomere repeat in chromosomes and cells. Recently, we developed a powerful single cell sequencing technique called Strand-seq. We now want to use...
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Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but extremely lethal ovarian cancer in young women due to lack of effective treatment. Our current study suggests that SCCOHT tumor cells need the activity of an enzyme called EZH2 for their survival. This enzyme adds methyl groups to the dedicated site of histones, a group of proteins that maintain the proper structure of DNA, and thereby controls which genes to turn on or off. Two EZH2 inhibitors, both in various clinical...
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Stat3 Regulates Centrosome Clustering in Cancer Cells via Stathmin/PLK1

Cancer cells have been observed to frequently have amplified centrosomes. These amplified centrosomes must be actively clustered together for cancer cells to divide. Since normal cells do not have centrosome amplification, targeting centrosome clustering is a highly specific way to target cancer cells while sparing normal cells. We performed an automated screen for compounds that inhibited centrosome clustering and identified a Stat3 inhibitor. We are currently trying...
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