MAP Kinase Signalling: Interplays Between Plant PAMP- and Effector-Triggered Immunity

In plants, mitogen-activated protein kinase (MAPK) cascades are involved in regulating many biological processes including immunity. They relay signals from membrane-residing immune receptors to downstream components for defense activation. Arabidopsis MPK3/6 and MPK4 are activated in two parallel MAPK cascades during PAMP-triggered immunity. MPK3/6 have been implicated in the activation of various immune responses and their inactivation leads to compromised…
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Dr. Donald Sin, Professor in the Division of Respiratory Medicine in the Department of Medicine at the University of British Columbia, was awarded a CIHR Planning and Dissemination Grant this past May. Find out which other Vancouver researchers were awarded grants, awards, fellowships, and scholarships last month in our May Award Summary!
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Historically, heparins were the mainstay of anticoagulant therapy. They were the primary agents used to treat deep vein thrombosis, arterial thromboembolism, and ischemic stroke. In spite of the introduction of anti-Xa and anti-thrombin agents to treat/prevent thrombosis, heparin continues to be used in major surgeries like cardio-pulmonary bypass to prevent blood clotting. Although heparins are effective in preventing blood clots,…
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Gender Equity In Health Research Funding

As BC’s health research funding agency, with a focus on talent development, we think deeply about how to best support BC health researchers and balance important considerations like equity and diversity. Although these issues are not ones the Foundation can solve singlehandedly, we are considering our role – and our responsibilities – as a funder in fostering equity in health…
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Chloe Gerak is a PhD candidate in the Department of Biochemistry and Molecular Biology at the UBC Life Sciences Institute. She is co-supervised by Dr. Lawrence McIntosh and Dr. Michel Roberge, and uses a combination of high-throughput screening, computational modeling, and NMR to find and characterize small molecule inhibitors of protein-protein interactions. We sat down with Chloe to discuss her research and the challenges she has faced throughout her time as a scientist.
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The Link between Diet, Gut Bacteria, and Kidney Stones

Studying partners’ habits leads researchers to breakthrough in kidney stone research. Kidney stones are a common problem in Canada. Ten per cent of the population suffers from the painful condition, caused when high levels of oxalate combine with calcium in the bloodstream and crystallize into stones in the kidney. Oxalates are found in a range of foods from french fries…
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Single-cell RNA-sequencing has great potential to discover cell types, identify cell states, trace development lineages, and reconstruct the spatial organization of cells. However, dimension reduction to interpret structure in single-cell sequencing data remains a challenge. Existing algorithms are either not able to uncover the clustering structures in the data or lose global information such as groups of clusters that are…
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Pixelating the Brain

MS/MRI research group applies machine learning techniques to neuroimaging data. “Think of an apple. An apple is round, sometimes it’s red, sometimes it has a stem,” says Marco Law. “We know one when we see one. But what if there’s more to an apple than we’re aware of? What if there are things about an apple that we haven’t noticed,…
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Today, HyperGrowth: Life celebrates the graduation of its second cohort — a group that promises to change the way we live, work and play with breakthroughs at the intersection of technology and the life sciences. Recognizing the tremendous potential that exists within the life sciences, in 2016 the BC Tech Association (BC Tech) partnered with Genome BC to create HyperGrowth:…
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