The state of North Carolina is home for Lumbee Native Americans. Approximately 1 in 5000 people of this population are affected by a severe disorder known as 'Native American Myopathy'.  Patients have severe muscle weakness and developmental defects. The root cause is a mutation in a gene known as 'STAC3'.  In this publication we studied the role of this protein and mapped the location of the genetic mutation on its 3D structure...
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It’s one of the most exciting, and controversial, areas of health science today: new technology that can alter the genetic content of cells, potentially preventing inherited disease — or creating genetically enhanced humans. But Canada is among the few countries in the world where working with the CRISPR gene-editing system on cells whose DNA can be passed down to future…
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Merck & CDRD Announce Joint Investment in the Canadian Life Sciences Ecosystem

The Canadian scientific community gathered in Ottawa this week to engage in a national dialogue on science, technology and innovation policy at the annual Canadian Science Policy Conference. Just prior to the Keynote Address at this event by the Honourable Kirsty Duncan, Minister of Science, Merck Canada Inc. and CDRD – The Centre for Drug Research and Development, announced the…
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Some postdoctoral researchers at public universities in the United States apparently work for fast-food wages whereas others make more than US$100,000 a year, an analysis of postdoc pay has revealed. The salary data, which a science-advocacy group released on 1 November after a year-long investigation, are incomplete and — in some cases — appear to be incorrect. Some researchers are listed as…
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Genome BC is pleased to announce a staged investment of $750,000 into CuePath Innovation (CuePath) through its Industry Innovation (I²) Program. CuePath is developing a connectivity platform for patients, their family members and professional caregivers, built around a novel form of smart medication packaging. By combining smart blister packs, cloud analytics and mobile applications, CuePath is increasing prescription adherence and…
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Applications Open For MSFHR’s 2018 Scholar Competition

Applications are now open for MSFHR’s 2018 Scholar competition. The letter of intent deadline is December 1, 2017, with full applications due February 2, 2018. Since 2001, the MSFHR Scholar Program has supported more than 400 early-career health researchers as they establish independent research careers, build leading health research programs and train junior scientists. Each award provides salary support for up…
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Alzheimer’s is the leading cause of dementia worldwide.  The incurable disease slowly impairs cognitive function, such as the ability to think and remember.  Because of these devastating effects on the brain, it has long been assumed that Alzheimer’s originates in the brain.  But new research has found that Alzheimer’s might be a disease that originates in other parts of the…
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Novel immune checkpoint blockade strategies are being evaluated in clinical trials and include targeting the lymphocyte activation gene 3 (LAG-3) checkpoint, alone or in combination with PD-1/PD-L1 blockade. We investigated LAG-3 expression and its prognostic value in a large series of breast cancer patients, and correlated LAG-3 expression with key biomarkers including PD-1 and PD-L1. LAG-3 expression was evaluated by…
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Myelodysplastic syndrome (MDS) represents a group of diseases often referred to as bone marrow failure, which usually develops in older people. In Canada alone, up to 6,000 new cases are diagnosed each year. The median survival for these patients ranges from 0.5 to 6 years after diagnosis. In healthy individuals, the bone marrow produces immature blood cells, which subsequently mature…
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