New MS Model Provides Hope for Better Understanding of Disease Pathology

Until now, researchers studying multiple sclerosis (MS) in mouse models have relied on models heavily weighted towards processes secondary to an autoimmune trigger. While discoveries made through these models have informed later translational research and clinical trials to improve drug treatment for people living with MS, a lack of a model for the unique biological process by which the disease…
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Congratulations to the CIHR 2017 Project Grant Recipients

We are pleased to congratulate the BC Children’s and BC Women’s investigators who were awarded funding from the Canadian Institutes of Health Research (CIHR) Fall 2017 competitions. Our research community received more than $8 million in new grants and awards. BC Children’s and BC Women’s investigators obtained 10 of the 59 full Project Grants awarded to UBC. Most of the investigators…
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Acute infection is known to induce strong anti-tumor immune responses, but clinical translation has been hindered by the lack of an effective strategy to safely and consistently provoke a therapeutic response. These limitations are overcome with a novel treatment approach involving repeated subcutaneous delivery of a Klebsiella-derived investigational immunotherapeutic, QBKPN. In preclinical models of lung cancer, QBKPN administration consistently showed anti-cancer…
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The British Columbia-led Digital Technology Supercluster is one of the funding recipients for the Government of Canada’s Innovation Supercluster Initiative, Minister Navdeep Bains announced today. In May 2017, Minister Bains announced a nationwide initiative to create up to five superclusters that will supercharge Canada’s regional innovation ecosystems and “build Canada as a global centre for innovation.” Superclusters are innovation hotbeds,…
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A particular gene mutation associated with an inherited form of Parkinson’s disease (PD) offers new clues that call into question a controversial theory that changes associated with PD may begin in a different area of the brain. Idiopathic PD, a spontaneous form of the disease, affects the dopamine system and is treated with replacement therapy to restore the brain’s chemical…
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In contrast with numerous studies of glutamate receptor-associated proteins and their involvement in the modulation of excitatory synapses, much less is known about mechanisms controlling postsynaptic GABAA receptor (GABAAR) numbers. Using tandem affinity purification from tagged GABAAR γ2 subunit transgenic mice and proteomic analysis, we isolated several GABAAR-associated proteins, including Cleft lip and palate transmembrane protein 1 (Clptm1). Clptm1 interacted with all…
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The frontoparietal control network (FPCN) plays a central role in executive control. It has been predominantly viewed as a unitary domain general system. Here, we examined patterns of FPCN functional connectivity (FC) across multiple conditions of varying cognitive demands, to test for FPCN heterogeneity. We identified two distinct subsystems within the FPCN based on hierarchical clustering and machine learning classification…
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An astonishing number of viruses are circulating around the Earth’s atmosphere – and falling from it – according to new research from scientists in Canada, Spain and the U.S. The study marks the first time scientists have quantified the viruses being swept up from the Earth’s surface into the free troposphere, that layer of atmosphere beyond Earth’s weather systems but…
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Zucara Therapeutics Receives Funding to Advance Lead Drug Candidate

Zucara Therapeutics Inc., a pre-clinical life sciences company advancing a novel long-term therapeutic approach to prevent hypoglycemia in patients with diabetes, has received support of up to $350,000 from the National Research Council of Canada Industrial Research Assistance Program (NRC IRAP). In addition, The Centre for Drug Research and Development (CDRD) and MaRS Innovation have contributed follow on funding to…
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Three faculty members have received the 2018 Canadian Association for Medical Education (CAME) Certificate of Merit Award. This award promotes, recognizes and rewards faculty committed to medical education in Canadian medical schools. The recipients, Drs. Brenda Hardie, Adam Peets and Joana Gil-Mohapel will be recognized at the Canadian Conference on Medical Education (CCME) in Halifax from April 28 to May 1,…
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