ICORD PIs Drs. Christ West and Brian Kwon have been awarded US$1.926 million by the US Department of Defense to study how changes to heart function following SCI can impact mobility. Their study, Offsetting cardiac dysfunction in acute spinal cord injury to optimize neurological outcome, will explore how the heart changes immediately at the time of injury and during the first hours-to-days after SCI. They will…
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The Faculty of Medicine received a total of $31.2 million  in the latest round of CFI funding, announced today at the Djavad Mowafaghian Centre for Brain Health (DMCBH). The eight projects represent the majority of the 15 grants, totaling $52.2 million, awarded to UBC. Three of these were awarded to DMCBH members. “Hearing about the scientists and researchers here at…
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This work was spearheaded by a former graduate student Michael Jones (5th from left) who performed the majority of the research at SFU, but in collaboration with his postdoctoral supervisors at the University of Calgary (Profs. Stys, Tsutsui, Wong), completed toxicity studies in neuronal culture. The major findings of this work were the multifunctional properties...
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InMed Pharmaceuticals Inc., a biopharmaceutical company specializing in the research and development of novel, cannabinoid-based drug therapies, is pleased to announce the addition of Dr. Mauro Maccarrone to its Scientific Advisory Board. Dr. Mauro Maccarrone is Professor and Chair of Biochemistry and Molecular Biology at Campus Bio-Medico, University of Rome. He also serves as Director of the Laboratory of Lipid Neurochemistry of the European Center…
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In the last week, two VPC researchers have been awarded grants to fund research projects aimed at improving the treatment prostate cancer. Dr. Alex Wyatt and his team, including Drs. Kim Chi and Faraz Hach, were awarded a Movember Discovery Grant for their project, “Genomic truncation of the Androgen Receptor in poor-prognosis castration-resistant prostate cancer.” Funded by the Movember Foundation, selected by…
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Self-Biotinylation of DNA G-Quadruplexes via Intrinsic Peroxidase Activity

The striking and ubiquitous in vitro affinity between hemin and DNA/RNA G-quadruplexes raises the intriguing possibility of its relevance to biology. To date, no satisfactory experimental framework has been reported for investigating such a possibility. Complexation by G-quadruplexes leads to activation of the bound hemin toward catalysis of 1- and 2-electron oxidative reactions, with phenolic compounds being particularly outstanding substrates.…
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The Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) Registry and Biobank is an international multi-centre study led by Dr Shubhayan Sanatani at the Children’s Heart Centre at BC Children’s Hospital (BCCH). CPVT is a rare (1:10,000) genetic heart condition characterized by an abnormal heart rhythm triggered by emotional stress or exercise. This abnormal rhythm may lead to cardiac arrest and/or death in…
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The BCIC Ignite Awards on October 10, 2017 awarded a total of $735,000 to the top four BC research projects in natural resources and applied sciences. Dr. Stephanie Willerth, Associate Professor of Mechanical Engineering at UVIC, who is working with Aspect Biosystems to develop functional, 3D bio printed human nerve tissues, that can recreate the pathology of neurodegenerative disorders such as Parkinson’s…
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Production of cancer-killing isotopes and creating more personalized treatments for respiratory diseases are among the eight projects receiving major grants from the Canada Foundation for Innovation. The Faculty of Medicine received a total of $31.2 in this latest round of CFI funding, and the eight projects represent the majority of the 15 grants, totaling $52.2 million, awarded to UBC. “Hearing…
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Selective Aggregation of the Splicing Factor Hsh155 Suppresses Splicing upon Genotoxic Stress

When a cell responds to DNA damage it must coordinate DNA repair with changes in both the transcriptome and proteome that together promote recovery and stress tolerance. Using a yeast model, this study identified a new way cells regulate gene expression under stress, namely, by disassembling a splicing complex called SF3B, and sequestering one of its core subunits in a nuclear protein aggregate...
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