Canadian researchers are raising concerns that the loss of a dedicated science minister signals a reduced voice for their agenda around the federal cabinet table. Wednesday’s announcement of the new federal cabinet included the revelation that Kirsty Duncan, most recently the minister of science and sport, has been moved from that post to deputy house leader. The science portion of…
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It has been shown that metastatic prostate cancers with mismatch repair defects are likely to respond to immune checkpoint inhibition, a class of therapy that has little efficacy in unselected patients. The authors demonstrated that mismatch repair defective metastatic prostate cancer can be identified and characterized using plasma circulating tumour DNA. They showed that it is not strictly necessary to identify the precise underlying defect because the signature of high tumour mutational burden and microsatellite instability can manifest at the genome-wide level, even in a liquid biopsy.
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Professor Wilfred Jefferies’ innovative strategies and outstanding inventions that enable cancer immunotherapies and vaccines have been recognized as it was announced that he has been elected as a Fellow of the National Academy of Inventors (NAI).  Election as a Fellow of the NAI is the highest professional distinction accorded solely to eminent academic inventors Professor Jefferies will be joining a prestigious group…
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Measuring the levels of insulin-like growth factor 2 receptor (IGF2R) during the first days of treatment with intravenous antibiotics could help predict treatment response in cystic fibrosis patients experiencing pulmonary exacerbations, a study has found. The study, “Identification of novel blood biomarkers of treatment response in cystic fibrosis pulmonary exacerbations by label-free quantitative proteomics,” was published in the journal Nature Scientific Reports. Pulmonary exacerbations are frequent among people…
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Novoheart (“Novoheart” or the “Company”) (TSXV: NVH; FWB: 3NH), a global stem cell biotechnology company, is pleased to announce a collaboration with global biopharmaceutical company AstraZeneca, in an effort to develop the world’s first human-specific in vitro, functional model of heart failure with preserved ejection fraction (HFpEF), a common condition especially among the elderly and in women, with the reported prevalence approaching…
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The recent announcement that an experimental Alzheimer’s drug is being resurrected after it was previously deemed a failure has made international headlines. Last month, biotech company Biogen said it would seek U.S. market approval for aducanumab, which, if approved, would become the first therapy to reduce the clinical decline of Alzheimer’s disease. The news came as a surprise to many. Last March,…
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Loss-of-function variants in ZDHHC9 have been identified in patients with X-linked intellectual disability (XLID), with ~2% of XLID patients exhibiting mutations in ZDHHC9. Patients with XLID plus ZDHHC9 mutations also have an elevated incidence of epilepsy compared to XLID patients with intact ZDHHC9. The authors demonstrated that loss of Zdhhc9 could increase the ratio of excitatory-to-inhibitory synapses and disrupt proper dendritic arborization, presenting a plausible mechanism for how loss of ZDHHC9 function may contribute to XLID and epilepsy.
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I’m pleased to announce the renewal and expansion of our Collaborative Research Mobility Awards (CRMA) program, a program which helps our research community establish new, or expand on existing, collaborations. The CRMA program facilitates collaboration on timely research opportunities between researchers in Vancouver and the Okanagan, helping them share knowledge, interests and access to equipment. These competitions are now running quarterly and have in…
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Dr. Connie Eaves, a professor of medical genetics at the University of British Columbia and distinguished scientist in the Terry Fox Laboratory at the BC Cancer Agency, has been a pioneer in leukemia and breast cancer research for five decades—so it’s no wonder she received two major accolades this year. In May, Eaves was inducted into the Canadian Medical Hall…
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