Pseudotime algorithms can be employed to extract latent temporal information from cross-sectional data sets allowing dynamic biological processes to be studied in situations where the collection of time series data is challenging or prohibitive. Computational techniques have arisen from single-cell ‘omics and cancer modelling where pseudotime can be used to learn about cellular differentiation or tumour progression. However, methods to…
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Roughly half of the western medicines used today were derived from naturally occurring plant metabolites. Plants produce over 200,000 of these specialized metabolites, but identifying medicinally useful ones is challenging, and obtaining sufficient quantities for human use poses an even greater challenge. Type-2 diabetes, a disease characterized by elevated blood glucose levels due to the body’s inefficient use of insulin,…
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Shortly after WAT Medical’s leading product to treat nausea-induced vomiting, EmeTerm, received its FDA clearance earlier in April, it has now also received official clearance from Health Canada. Health Canada ensures all of its certified medical products are of the highest quality and are able to provide the best care for patients to improve their lives. WAT Medical has reached…
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​Breast cancer is the most common cancer in women with one in nine developing the disease in her lifetime. This year, approximately 3,500 new cases of breast cancer are expected in the province of British Columbia. Treatments include surgery, radiation, chemotherapy, hormonal therapy or a combination depending on an individual’s disease. Now a new international study published in New England Journal of Medicine,…
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Mechanics-Guided Developmental Fate Patterning

A micropatterned human pluripotent stem cell-based developmental model was utilized to demonstrate the role of biophysical cues such as cell size and cytoskeletal contractile forces in directing patterning of neuroepithelial and neural plate border cells. During embryonic development, cells in different locations of the embryo acquire different fates in a self-organized process called fate patterning. The process of how an…
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Five FHS graduate students, who are citizens of Kenya, Botswana and Rwanda, were recently admitted as research fellows into the Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE) consortium. The fellowship recipients are Khumoekae Richard (PI: Ian Tietjen), Gisele Umviligihozo (PI: Mark Brockman), Lorato Maje (PI: Angela Kaida), Fredrick Omondi (PI: Zabrina Brumme) and Grace Mwashigadi (MPH programme). SANTHE connects students with a multinational network…
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IFNγ stimulates differentiation to pro-inflammatory (M1, classically-activated) macrophages. In this publication, we demonstrate that proteolytic processing at the C-terminus of IFNγ by matrix metalloproteinase-12 (MMP-12) prevents IFNγ signaling. Systemic lupus erythematosus (SLE) patients have decreased MMP-12 expression compared with healthy controls, and in murine models of lupus and arthritis, mice with deleted or inhibited MMP-12 have worse disease…
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Cervical cancer is among the easiest gynecologic cancers to prevent, and two screening tests can help detect the disease early: the routine Pap smear and testing for human papillomavirus, or HPV. The cytology-based Pap smear involves looking for cancer or precancer cells by testing cells taken from the lower end of a woman’s uterus, called the cervix. Diagnosing diseases by looking at single…
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Cancer is one of the biggest health crises of our generation – statistics now indicate that nearly half of all Canadians will be diagnosed during their lifetime. And while an increasing number of Canadians are surviving at least five years past their diagnosis, cancer continues to be the leading cause of death in Canada. However, Microsoft Canada announced a partnership with BC Cancer yesterday…
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