MSFHR to Provide Match Funds on CIHR Patient-Oriented Research Grants

At MSFHR we partner to grow BC research talent in two main ways: inviting organizations to co-fund MSFHR awards, and contributing match funding for BC researchers applying for national and international projects that address our province’s health system priorities. This match funding enables BC researchers to participate in national and international research, build connections and apply their learnings to the BC…
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Dr. Manish Sadarangani Named Sauder Chair in Pediatric Infectious Diseases

Congratulations to Dr. Manish Sadarangani on his recent appointment as the Sauder Chair in Pediatric Infectious Diseases at the University of British Columbia. Funded by a donation from the Sauder Family, the Chair supports research to improve the prevention, diagnosis and treatment of childhood infectious diseases. When it comes to saving the lives of kids with serious infections, Dr. Sadarangani believes “the…
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New Class of Glycoside Hydrolase Mechanism-Based Covalent Inhibitors: Glycosylation Transition State Conformations

The design of covalent inhibitors in glycoscience research is important for the development of chemical biology probes. Here we report the synthesis of a new carbocyclic mechanism-based covalent inhibitor of an α-glucosidase. The enzyme efficiently catalyzes its alkylation via either an allylic cation or a cationic transition state. We show this allylic covalent inhibitor has different catalytic proficiencies for pseudoglycosylation…
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Aequus Pharmaceuticals Inc., a specialty life sciences company focused on providing patients with differentiated and enhanced delivery systems for existing and approved drugs, and Scientus Pharma Inc., a biopharmaceutical company focused on R&D and product commercialization for extracts and formulations related to medical cannabinoids and their derivatives, announced today that they have signed a non-binding term sheet on a collaboration…
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Oral sucrose is administered routinely to reduce pain of minor procedures in premature infants and is recommended as standard care in international guidelines. No human or animal studies on effects of early repeated sucrose exposure on long-term brain development have been done in the context of pain. We evaluated the effects of repeated neonatal sucrose treatment before an intervention on…
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Yes, you read that right: Getting dirty may reduce your risk of depression. But before you start rolling in the mud or even worse, eating it, let’s take a step back. The hygiene hypothesis has been bandied about for ages. In a nutshell, it suggests that we are too clean, which is why we get sick. Early childhood is the time when…
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The past decade has brought tremendous progress in unraveling the pathophysiology of Alzheimer’s disease (AD). While increasingly sophisticated immunotherapy targeting soluble and aggregated brain amyloid-beta (Aβ) continues to dominate clinical research in AD, a deeper understanding of Aβ physiology has led to the recognition of distinct neuronal signaling pathways linking Aβ to synaptotoxicity and neurodegeneration and to new targets for…
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Continuing their longstanding tradition of partnering to fund high quality Canadian prostate cancer research, Prostate Cancer Canada (PCC) and The Movember Foundation today announced two new projects with very real potential to make a tangible difference in the lives of men living with aggressive forms of prostate cancer. Dr. Amina Zoubeidi is one of the recipients, for a project to…
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Prioritizing molecular alterations that act as drivers of cancer remains a crucial bottleneck in therapeutic development. Here we introduce HIT’nDRIVE, a computational method that integrates genomic and transcriptomic data to identify a set of patient-specific, sequence-altered genes, with sufficient collective influence over dysregulated transcripts. HIT’nDRIVE aims to solve the “random walk facility location” (RWFL) problem in a gene (or protein)…
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The use of medication in modern medicine has revolutionized healthcare and made a significant impact on patient longevity and quality of life. Unfortunately, many medications can also cause unintended side effects – also known as adverse drug reactions (ADRs). In an effort to reduce severe ADRs in Canada, researchers at the University of British Columbia (UBC) and the BC Children’s…
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