An international clinical trial has found that a new drug for Huntington disease is safe, and that treatment with the drug successfully lowers levels of the abnormal protein that causes the debilitating disease in patients. In the study published today in the New England Journal of Medicine, researchers from UBC and their colleagues have demonstrated for the first time that the…
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Regulatory programs that control the function of stem cells are active in cancer and confer properties that promote progression and therapy resistance. However, the impact of a stem cell-like tumor phenotype (“stemness”) on the immunological properties of cancer has not been systematically explored. Using gene-expression–based metrics, we evaluated the association of stemness with immune cell infiltration and genomic, transcriptomic, and…
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In order to diagnose a cancer, pathologists use a variety of techniques to analyze the features of a tissue biopsy. This works best when the specimen being analyzed is of high quality, contains many cells and has clearly identifiable features. Unfortunately, this is not always the case, and rare cancers are especially difficult to diagnose using traditional diagnostic methods. Cancers…
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Research funding often has restrictions and may not provide a scientist with an opportunity to truly explore beyond the parameters of the grant that supports their work. However, the St. Baldrick’s Foundation Robert J. Arceci Innovation Award allows researchers to do just that with the hopes that the freedom will lead to breakthroughs in the treatment of childhood cancers. This year’s U.S.…
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UBC research into green chemistry and microbial bioremediation are among five UBC projects receiving funding through the Natural Sciences and Engineering Research Council of Canada’s (NSERC) Strategic Partnership Grants program. “When researchers, businesses and governments work together, they can turn their discoveries into the innovations that will improve the lives of all Canadians,” said Kirsty Duncan, Minister of Science and Sport, in making…
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Dr. Michael Hawes, CEO of Fulbright Canada, and Dr. Alejandro Adem, CEO of Mitacs, are pleased to announce the Fulbright Canada – Mitacs Globalink Research program to support student mobility and educational exchange between Canada and the United States of America. This partnership will leverage Mitacs’s expertise in supporting research-based innovation and Fulbright Canada’s standing as a global leader in…
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In Escherichia coli, the peptidoglycan crosslinking reaction to form the cell wall is primarily carried out by penicillin-binding proteins that catalyse D,D-transpeptidase activity. However, an alternate crosslinking mechanism involving the L,D-transpeptidase YcbB can lead to bypass of D,D-transpeptidation and beta-lactam resistance. Due to the important roles YcbB can undertake during stress and infectious conditions, it is a promising target for the development of novel and specific antibacterial therapies.
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Congratulations to Dr. Connie J. Eaves, Professor of Medical Genetics at the University of British Columbia and Distinguished Scientist at the Terry Fox Laboratory, BC Cancer, on winning the 2019 Canadian Gairdner Wightman Award. The recognition honours scientists who make transformative contributions to research that impact human health. For more information can be found on the Gairdner Awards website.
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Ibrutinib (IB) is an oral Bruton’s tyrosine kinase (BTK) inhibitor that has demonstrated benefit in B cell cancers, but is associated with a dramatic increase in atrial fibrillation (AF). We employed cell-specific differentiation protocols and optical mapping to investigate the effects of IB and other tyrosine kinase inhibitors (TKIs) on the voltage and calcium transients of atrial and ventricular human…
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One-On-One with Dr. David Granville

On March 1, 2019, Dr. David Granville was appointed to the position of Associate Director of the Vancouver Coastal Health Research Institute (VCHRI). In this role, he will oversee innovation and research activities within the VCH research community, including the internal awards program, medical animal facilities, Legacy Research Program, Centre for Heart and Lung Health and the Immunity and Infection…
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