Fixation Effects on Variant Calling in a Clinical Resequencing Panel

Formalin fixation is the standard method for the preservation of tissue for diagnostic purposes, including pathologic review and molecular assays. However, this method is known to cause artifacts that can affect the accuracy of molecular genetic test results. We assessed the applicability of alternative fixatives to determine whether these perform significantly better on next-generation sequencing assays, and whether adequate morphology…
Read More
Mani Larijani’s home base is in SFU’s Department of Molecular Biology and Biochemistry, but his research spills into evolutionary and cellular biology, genetics, immunology, oncology, computational science and health science. Larijani’s multi-disciplinary research program on DNA/RNA mutating processes led him to his new appointment as the Shrum Chair in Biological Mechanisms of Disease. Larijani comes to SFU from Memorial University…
Read More
Two members of the Faculty of Medicine community will be appointed to the Order of British Columbia for 2019, which is the 30th anniversary of the Order. Bruce McManus and Kimit Rai are among 15 recipients and five from UBC to receive the honour this year. Bruce McManus, a professor in the Department of Pathology and Laboratory Medicine, has had a major influence in…
Read More
When the human genome was sequenced 20 years ago, there was a great excitement at the possibility of personalized medicine. Once the genetic makeup of a person’s disease was known, hopes were high that researchers could design specifically matched and targeted treatment for many patients. It turns out, dealing with real-world disease is not so straightforward. Now scientists at the…
Read More
Abstract Background Azithromycin reduces pulmonary exacerbation (PEx) risk in cystic fibrosis (CF) but not all individuals benefit. The goal of this study was to discover blood protein biomarkers predictive of clinical response to azithromycin treatment in CF children and adolescents. Methods Novel proteomic technologies were applied to examine 188 serum and plasma proteins from 40 CF subjects randomized to azithromycin…
Read More
Following on the announcement in Budget 2019, the Canadian Institutes of Health Research, the Natural Sciences and Engineering Research Council and the Social Sciences and Humanities Research Council are pleased to announce that the duration of a paid parental leave for graduate students and postdoctoral fellows supported by the agencies is being doubled. The maximum duration will be twelve months…
Read More
Dr. Erin Michalak is the winner of the 2018 CIHR Gold Leaf Prize for Transformation: Patient Engagement. Dr. Michalak is being recognized for her work founding the Collaborative RESearch Team to study psychosocial issues in Bipolar Disorder (CREST.BD), and its groundbreaking participatory approach that allows people with bipolar disorder, researchers and clinicians to collaborate on research and knowledge translation projects. Dr.…
Read More
A tentative agreement reached between the Trudeau government and Canada’s scientists would lock in their right to speak to the media about science and their work for another four years. The “scientific integrity” clause was first written into a 2017 collective agreement and enshrined the right to speak about science and their research without being designated a departmental spokesperson. The Liberals, under Prime Minister…
Read More

Indigenous Diversity in Science Research

As a member of Soda Creek Indian Band in British Columbia, Olivia Baptiste grew up as an athlete. She learned about science in high school, but never pictured herself to set foot inside a research laboratory. It wasn’t until 2015 that an opportunity ignited her passion for science research. In grade ten, Baptiste participated in the Verna J. Kirkness Science and…
Read More
Dr. Kim Nguyen Chi, a respected prostate cancer researcher and oncologist, will take over as head of B.C. Cancer on July 1. He is the first visible minority leader since the agency was established 45 years ago. Chi, who earned his medical degree at the University of Ottawa, succeeds Dr. Malcolm Moore, who announced four months ago that he would be leaving the post about…
Read More